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Majalah Patologi Indonesia

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Published by Perhimpunan Ahli Patologi Indonesia

ISSN : 02157284 EISSN : 25279106 DOI : https://doi.org/10.55816/

Core Subject : Health,

Health Professions Public Health

Majalah Patologi Indonesia (MPI) digunakan sebagai wahana publikasi hasil penelitian, tinjauan pustaka, laporan kasus dan ulasan berbagai aspek di bidang patologi manusia. Tujuannya ialah menghadirkan forum bagi permakluman dan pemahaman aneka proses patologik serta evaluasi berbagai penerapan cara diagnostik sejalan dengan kemajuan perkembangan ilmu dan teknologi. Selain itu juga untuk merangsang publikasi barbagai informasi baru/mutakhir.

Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan

Articles 7 Documents

Search results for , issue "Vol 29 No 3 (2020): MPI" : 7 Documents clear

Deteksi Mikrometastasis pada Bulky Kelenjar Getah Bening Karsinoma Serviks Stadium IA-IIB Menggunakan Sitokeratin AE1/AE3 Reni Angeline; Hartono Tjahjadi; Puspita Eka Wuyung
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundCervical uterine carcinoma is a primary malignant disease of the uterine cervix. The presence or absence of metastasis in lymphnodes does not alter the stage but affects recurrence, survival, and therapy. Immunohistochemistry stains of the AE1/AE3cytokeratin can assist in the diagnosis and determine the small focus of carcinoma metastasis. In this study, we analyzedimmunohistochemistry cytokeratin AE1/AE3 could determine micrometastasis in bulky lymph nodes negative.MethodsThis study used cross-sectional design. The sample consisted of 52 cases of stage IA-IIB cervical carcinoma performed by radicalhysterectomy and lymphadenectomy accompanied by negative bulky lymph nodes at the Department of Anatomical PathologyFaculty of Medicine University of Indonesia/Cipto Mangunkusumo Hospital (FKUI/RSCM) from January 2011 to June 2017. Allcases stained by immunohistochemistry cytokeratin AE1/AE3.ResultsBulky Lymph Nodes Cervical Carcinoma stage IA-IIB, histopathologic diagnose of non keratinized squamous cell carcinoma,moderate differentiation degree, no lymphovascular invasion and deepest invasion >5.0 mm. Immunohistochemistry staining ofAE1/AE3 cytokeratin showed no micrometastasis in all cases.ConclusionThe immunohistochemistry staining of AE1/AE3 cytokeratin used in Bulky Lymph Nodes Cervical Carcinoma stage IA-IIB could notdetected micrometastasis in all cases.

Hubungan Ekspresi IGF-1R dan HER-2 Terhadap Jumlah Mitosis dan Derajat Histopatologik pada Karsinoma Payudara Invasif Tidak Spesifik Yessy Setiawati; Aswiyanti Asri; Rosfita Rasyid
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundThe IGF-1R signaling pathways have cross-talk with HER-2 signaling pathways and was thought to be one of the resistance mechanism intrastuzumab therapy. This research was proposed to analyze the correlation between IGF-1R and HER-2 expression with mitosis count andhistopathological grade in invasive breast carcinoma of no special type.MethodsThis research was a cross-sectional design. A total of fifty-five invasive breast carcinoma of no special type cases diagnosed in theAnatomical Pathology Centre Diagnostic of Medical Faculty of Andalas University in a period of 2014-2015 were collected and stainedimmunohistochemically with IGF-1R and HER-2 antibodies. IGF-1R and HER-2 expression were examined and their correlation with mitosiscount and histopathological grade were statistically analyzed with T-test, Oneway Anova and Chi-Square test.ResultsIGF-1R cytoplasm and membranous expression were found positive in 18.2% and 34.5% cases respectively, meanwhile, HER-2 expressionswere found positive in 23.6% cases of invasive breast carcinoma of no special type. There were significant correlations between IGF-1Rcytoplasm expression with mitosis count (p=0.049). There were no significant correlations between IGF-1R membranous expression withmitosis count (p=0.641) with histopathological grade (p=1.00). There were no significant correlations between HER-2 expression withmitosis count (p=0,495) and histopathological grade (p=1.000).ConclusionIGF-1R expressions have a significant correlation with mitosis count rather than HER-2 expressions. Inhibition it’s signaling pathways mayhave therapeutic value in breast carcinoma. Combination therapy of anti-HER-2 and anti-IGF-1R are expected to overcome resistance withtrastuzumab in HER-2 positive breast carcinoma

Analisis Ekspresi BRAF dan TERT pada Kasus Papillary Thyroid Carcinoma Berdasarkan Stratifikasi Risiko ATA Cempaka Harsa Sekarputri,; Etty Hary Kusumastuti,; Gondo Mastutik
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundPapillary thyroid carcinoma (PTC) is the most common malignancy in thyroid, accounting for more than 80% of all thyroid cancer.Rrecurrences of the disease reach 30% cases. It has been widely observed that BRAF and TERT is associated with aggressivenessbehaviors in human cancer. Both are involved in the pathogenesis of PTC that may be used as targets for new therapies. AmericanThyroid Association (ATA) risk stratification can define the risk of recurrence in PTC. No marker has been found to determine therisk of PTC recurrence. The purpose of this study is to analyzed BRAF and TERT expression in ATA risk stratification system inPTC classic variant samples.MethodsThe methods of this study is an analytical observational study with cross sectional approach, conducted on 56 samples of PTCclassic variant selected from Department of Anatomical Pathology Dr. Soetomo General Hospital between January 2015-December2017 by determined criteria in ATA risk stratification groups of low risk, intermediate risk and high risk. The expression BRAF andTERT observed using immunohistochemical staining of Santa Cruz monoclonal antibody.ResultsThe result for each group based on ATA risk stratification groups of low risk were 13 samples (23.20%), intermediate risk were 25samples (44.62%) and high risk were 18 samples (32.12%).The correlation was assessed with Spearman’s rho correlation test. There is significant correlation BRAF (p=0.004) with a value ofr=0.374 and TERT(p=0.032) with a value of r=0.287 for ATA risk stratification.ConclusionBRAF and TERT expression showed significant correlation to ATA risk stratification in classic variant PTC.

Karakteristik Klinikohistopatologik dan Profil Imunofluoresensi Kasus Pemfigoid bulosa di Departemen Patologi Anatomik Rumah Sakit Cipto Mangunkusumo Tahun 2011-2018 Fetisari Kurniawan; Riesye Arisanty
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundBullous pemphigoid is the most common autoimmune bullous disease. It is characterized by the presence of autoantibodies againsthemidesmosomal proteins in dermo-epidermal junction. Immune complexes subsequently induce skin blisters formation clinically, which willappear as subepidermal cleft histopathologically, and revealed as immune depositions immunologically. These three findings are required inorder to estabilsh the diagnosis of Bullous pemphigoid. This study was aimed to asses the clinico histopathological characteristics andimmunofluorescence studies of bullous pemphigoid in Anatomical Pathology Department, Cipto Mangunkusumo General Hospital.MethodsA cross sectional study was conducted in Anatomical Pathology Department ,Cipto Mangunkusumo General Hospital from January 2011 toDecember 2018. Clinical, histopathological, and direct immunofluorescence results were evaluated.ResultsDuring the last 8 years, bullous pemphigoid was the second most common form of autoimmune bullous diseases. The mean age of thesample was 60 years old. Women were affected more common than men (61.6%). Majority of patients present with blisters eruption (67.4%)and most commonly found in the lower extremities (48.8%). Histopathological examinations showed mostly a subepidermal cleft (89.5%)containing infiltrates of eosinophil, neutrophil, and lymphocyte. DIF staining demonstrated 31 cases (36.0%) with immune depositscharacteristic for bullous pemphigoid.ConclusionThe diagnosis of bullous pemphigoid is relied on a combination of clinical, histopathological, and direct immunofluorescence findings.

Ekspresi AgNOR dan Ekspresi Ki-67 pada Grading Adenokarsinoma Prostat Roza Rita; Delyuzar; Lidya Imelda Laksmi
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundProstate cancer is the second most common cancer and fifth most common cancer cause of death in males. Tissue biopsy is a goldstandard examination to diagnose prostate cancer. One of the hallmarks of cancer is increased activity of cell proliferation. Thisactivity can be detected with Ki-67 and AgNOR (Argyrophilic nucleolar organizing region). The aim of this study is to analyzedcorrelation between AgNOR and Ki-67 expression in grading of prostated adenocarcinoma.MethodsThis analytic cross-sectional study was held in Laboratory of Anatomical Pathology of Medical Faculty of USU/ RSUP H. AdamMalik Medan. Thirty paraffin blocks diagnosed with prostate adenocarcinoma were stained with H&E and p63 immunohistochemistrythen evaluated based on Gleason’s histopathological grading and stained with Agnor and Ki 67.ResultsAgNOR expression yang diperoleh pada grading adenokarsinoma prostat group 1, 2, 3, 4, dan 5 berturut-turut adalah 43; 32,40(±14,54); 64,29 (±28,2); 59,5 (±28,32); 69,22 (±29,26). Ekspresi Ki-67 pada setiap grading adenokarsinoma prostat group 1, 2, 3, 4,dan 5 secara berurutan adalah 43; 32,4 (±14,53); 64,29 (±28,2), 59,5 (±28,31); 69,22 (±29,26). Statistical analyses showed thatthere was no significantly correlation between grading of prostate adenocarcinoma and AgNOR expression (p=0.065), and Ki-67expression (p=0.18). Nevertheless, a significantly correlation between KI-67 expression and grading of prostate adenocarcinomawas found (p=0.34).ConclusionKi-67 could be used as prognostic indicator for prostate adenocarcinoma.

Hubungan Kepadatan Infiltrasi Sel Radang Limfosit dengan Klinikopatologik Karsinoma Kolorektal di RSUP Dr. Mohammad Hoesin Palembang Calvin Ienawi; Suly Auline Rusminan; Zen Hafy
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundColorectal carcinoma has become one of primary problem that caused mortality and morbidity around the world. This malignancyhas contributed almost more than 9% of all cancer incidence. Lymphocyte infiltration density (TILs) is one of prognostic factors toevaluate colorectal cancer. Although some studies have found that there still have variations in sassociation lymphocyte density withclinicopathology of colorectal carcinoma which related to patient prognosis. This study was aimed to identify and analyze theassociation of lymphocyte density with clinicopathological colorectal carcinoma patients in Dr. Mohammad Hoesin General HospitalPalembang.MethodsA total of 41 HE stained slides which were diagnosed as colorectal carcinoma were observed under the light microscope.Lymphocytes were counted in five different areas that showed the highest lymphocytes density. The mean values of the lymphocytewere received from those five different areas. Determination of cutoff point was counted from the median of all mean value of thelymphocytes and being classified to become two categories, high-density lymphocytes and low-density lymphocytes.ResultsOut of 41 subjects, most patients have tumor size more than/or equal to 5 cm (63.4%), the tumors are often found in the left-sided ofcolon (39.0%), have moderate differentiated degree (65.9%), are included into T3 in tumor staging (48.8%), and no regional lymphnodes metastasis (39.0%). The most histopathological classification is adenocarcinoma (41.5%). Bivariate analysis showed thatlymphocyte density has correlation with tumor differentiation degree (p=0.021) and histopathological classification (p=0.004).ConclusionLymphocyte infiltration density has correlation with degree differentiation and histopathological classification of colorectal carcinomain Dr. Mohammad. Hoesin General Hospital-Palembang

Ekspresi Programmed Death Ligand-1 (PD-L1) pada Seminoma Testis sebagai Potensi Faktor Prognostik Freciyana Boedijono; Budiana Tanurahardja; Ria Kodariah
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundThe prognosis of testicular seminoma cases which failed to be cured with conventional therapy is poor. Several recurrent eventsafter chemotherapy were also found. PD-L1 is expressed in various types of malignancy and tumor infiltrating lymphocytes (TILs)and its role is known as a prognostic factor. This study was conducted to determine the role of PD-L1 expression seminoma indetermining overall survival (OS) and progression free survival (PFS).MethodsThis is a retrospective cohort study with survival analysis. Clinical data were obtained from medical record in RSUPN CiptoMangunkusumo since January 2011-December 2016 and observed for 2 years. Histopathological data were obtained fromAnatomical Pathology Department and PD-L1 immunohistochemical staining were performed.ResultsA significant correlation between PD-L1 expression in tumor cells with 2-year OS (p=0.023) and PFS (p=0.002) in testicularseminoma was found. No significant correlation between PD-L1 expression in TILs with 2-year OS (p=0.235) and PFS (p=0.111).We also found significant correlations between PD-L1 expression of tumor cells and TILs with PFS (p=0.019). A significantcorrelation between stage with 2-year OS (p=0.010) and PFS (p=0.000) and lymph node metastases with 2-year OS (p=0.010) andPFS (p=0.000).ConclusionPD-L1 expression of testicular seminoma cells were significantly correlated with OS and PFS. There were no statistically significantassociations between PD-L1 expression in TILs with OS and PFS.

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